In stent restenosis: bane of the stent era
نویسندگان
چکیده
منابع مشابه
In-stent restenosis in the drug-eluting stent era.
The introduction of the drug-eluting stent (DES) proved to be an important step forward in reducing rates of restenosis and target lesion revascularization after percutaneous coronary intervention. However, the rapid implementation of DES in standard practice and expansion of the indications for percutaneous coronary intervention to high-risk patients and complex lesions also introduced a new p...
متن کاملInflammation and restenosis in the stent era.
The pathophysiology of restenosis involves early elements of direct injury to smooth muscle cells, deendothelialization, and thrombus deposition. Over time, this leads to smooth muscle cell proliferation/migration and extracellular matrix deposition. There is an increasing body of evidence to suggest that inflammation plays a pivotal role linking early vascular injury to the eventual consequenc...
متن کاملOverview of Intracoronary Brachytherapy for in-Stent Restenosis of a Drug-Eluting Stent
Percutaneous coronary intervention with stenting is considered recently as the most common procedure for the treatment of symptomatic coronary. The article reviewed 41 studies published during 1997-2019 on intracoronary brachytherapy for in-stent restenosis of a drug-eluting stent. Intracoronary radiation therapy was finally confirmed in the setting of in-stent restenosis using as adjunctive th...
متن کاملReducing In-Stent Restenosis
All animal procedures were performed in accordance with UK Home Office Guidance on the operation of the Animals (Scientific Procedures) Act 1986 and institutional ethical approval (PPL60/4114 and PPL 60/4429). Male white Landrace pigs (SAC Commercial Ltd, Edinburgh, UK) and miR-21 knockout mice (1) were maintained on a 12 hour light/dark cycle with free access to food and water at a designated ...
متن کاملIn-Stent Restenosis?
The introduction of bare metal stents (BMS) over 30 years ago was a significant milestone in the evolution of percutaneous coronary intervention. Soon after, it was apparent that these stents led to a troubling phenomenon of in-stent restenosis (ISR), which requires repeat revascularization, was associated with increased morbidity and mortality, and posed a therapeutic challenge. The quest for ...
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ژورنال
عنوان ژورنال: Journal of Clinical Pathology
سال: 2006
ISSN: 0021-9746
DOI: 10.1136/jcp.2005.025742